Control of lymphatic filariasis in a hunter-gatherer group in Madang Province.
Identifieur interne : 012E28 ( Main/Exploration ); précédent : 012E27; suivant : 012E29Control of lymphatic filariasis in a hunter-gatherer group in Madang Province.
Auteurs : M J Bockarie ; C. Jenkins ; W M Blakie ; M. Lagog ; M P AlpersSource :
- Papua and New Guinea medical journal [ 0031-1480 ]
Descripteurs français
- KwdFr :
- Diéthylcarbamazine (administration et posologie), Diéthylcarbamazine (usage thérapeutique), Facteurs temps, Filaricides (administration et posologie), Filaricides (usage thérapeutique), Filariose lymphatique (), Filariose lymphatique (épidémiologie), Humains, Papouasie - Nouvelle-Guinée (épidémiologie), Population de passage et migrants (), Résultat thérapeutique.
- MESH :
- administration et posologie : Diéthylcarbamazine, Filaricides.
- usage thérapeutique : Diéthylcarbamazine, Filaricides.
- épidémiologie : Filariose lymphatique, Papouasie - Nouvelle-Guinée.
- Facteurs temps, Filariose lymphatique, Humains, Population de passage et migrants, Résultat thérapeutique.
- Wicri :
- geographic : Papouasie-Nouvelle-Guinée.
English descriptors
- KwdEn :
- Diethylcarbamazine (administration & dosage), Diethylcarbamazine (therapeutic use), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (prevention & control), Filaricides (administration & dosage), Filaricides (therapeutic use), Humans, Papua New Guinea (epidemiology), Time Factors, Transients and Migrants (statistics & numerical data), Treatment Outcome.
- MESH :
- chemical , administration & dosage : Diethylcarbamazine, Filaricides.
- chemical , therapeutic use : Diethylcarbamazine, Filaricides.
- geographic , epidemiology : Papua New Guinea.
- epidemiology : Elephantiasis, Filarial.
- prevention & control : Elephantiasis, Filarial.
- statistics & numerical data : Transients and Migrants.
- Humans, Time Factors, Treatment Outcome.
Abstract
Diethylcarbamazine (DEC) has been successfully administered to millions of people in established villages and towns, but little or no information exists on the use of this drug to control lymphatic filariasis in isolated seminomadic groups. We have studied the impact of biannual single-dose mass treatment to control filariasis in the Hagahai, an isolated hunter-gatherer, shifting horticulturist group in the fringe highlands of Papua New Guinea. Despite low treatment coverage, 6 mass treatment rounds significantly reduced the overall prevalence of infection with Wuchereria bancrofti, by antigen detection assay, from 55% before treatment to 34% after treatment. Obstructive filarial disease in the form of elephantiasis or hydrocele was not observed among the indigenous population. Anopheles species accounted for 91% of human-biting mosquitoes collected in the area. A total of 1126 mosquitoes were caught and dissected individually but none was infected with third-stage larvae (L3). Our findings support the phenomenon of facilitation, which predicts that Anopheles-transmitted lymphatic filariasis can be interrupted by mass chemotherapy alone in areas of low vector density and low transmission intensity as observed in the Hagahai.
PubMed: 11939301
Affiliations:
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Le document en format XML
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Lagog</name></author><author><name sortKey="Alpers, M P" sort="Alpers, M P" uniqKey="Alpers M" first="M P" last="Alpers">M P Alpers</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2000 Sep-Dec</MedlineDate></PubDate></date><idno type="RBID">pubmed:11939301</idno><idno type="pmid">11939301</idno><idno type="wicri:Area/PubMed/Corpus">004616</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004616</idno><idno type="wicri:Area/PubMed/Curation">004616</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">004616</idno><idno type="wicri:Area/PubMed/Checkpoint">004616</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">004616</idno><idno type="wicri:Area/Ncbi/Merge">000924</idno><idno type="wicri:Area/Ncbi/Curation">000924</idno><idno type="wicri:Area/Ncbi/Checkpoint">000924</idno><idno type="wicri:doubleKey">0031-1480::Bockarie M:control:of:lymphatic</idno><idno type="wicri:Area/Main/Merge">014047</idno><idno type="wicri:Area/Main/Curation">012E28</idno><idno type="wicri:Area/Main/Exploration">012E28</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Control of lymphatic filariasis in a hunter-gatherer group in Madang Province.</title><author><name sortKey="Bockarie, M J" sort="Bockarie, M J" uniqKey="Bockarie M" first="M J" last="Bockarie">M J Bockarie</name><affiliation><nlm:affiliation>Papua New Guinea Institute of Medical Research, Madang Province.</nlm:affiliation><wicri:noCountry code="subField">Madang Province</wicri:noCountry></affiliation></author><author><name sortKey="Jenkins, C" sort="Jenkins, C" uniqKey="Jenkins C" first="C" last="Jenkins">C. Jenkins</name></author><author><name sortKey="Blakie, W M" sort="Blakie, W M" uniqKey="Blakie W" first="W M" last="Blakie">W M Blakie</name></author><author><name sortKey="Lagog, M" sort="Lagog, M" uniqKey="Lagog M" first="M" last="Lagog">M. Lagog</name></author><author><name sortKey="Alpers, M P" sort="Alpers, M P" uniqKey="Alpers M" first="M P" last="Alpers">M P Alpers</name></author></analytic><series><title level="j">Papua and New Guinea medical journal</title><idno type="ISSN">0031-1480</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Diethylcarbamazine (administration & dosage)</term><term>Diethylcarbamazine (therapeutic use)</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (prevention & control)</term><term>Filaricides (administration & dosage)</term><term>Filaricides (therapeutic use)</term><term>Humans</term><term>Papua New Guinea (epidemiology)</term><term>Time Factors</term><term>Transients and Migrants (statistics & numerical data)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Diéthylcarbamazine (administration et posologie)</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Facteurs temps</term><term>Filaricides (administration et posologie)</term><term>Filaricides (usage thérapeutique)</term><term>Filariose lymphatique ()</term><term>Filariose lymphatique (épidémiologie)</term><term>Humains</term><term>Papouasie - Nouvelle-Guinée (épidémiologie)</term><term>Population de passage et migrants ()</term><term>Résultat thérapeutique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Diethylcarbamazine</term><term>Filaricides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term><term>Filaricides</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Papua New Guinea</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Diéthylcarbamazine</term><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Transients and Migrants</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Diéthylcarbamazine</term><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Papouasie - Nouvelle-Guinée</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Facteurs temps</term><term>Filariose lymphatique</term><term>Humains</term><term>Population de passage et migrants</term><term>Résultat thérapeutique</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Papouasie-Nouvelle-Guinée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Diethylcarbamazine (DEC) has been successfully administered to millions of people in established villages and towns, but little or no information exists on the use of this drug to control lymphatic filariasis in isolated seminomadic groups. We have studied the impact of biannual single-dose mass treatment to control filariasis in the Hagahai, an isolated hunter-gatherer, shifting horticulturist group in the fringe highlands of Papua New Guinea. Despite low treatment coverage, 6 mass treatment rounds significantly reduced the overall prevalence of infection with Wuchereria bancrofti, by antigen detection assay, from 55% before treatment to 34% after treatment. Obstructive filarial disease in the form of elephantiasis or hydrocele was not observed among the indigenous population. Anopheles species accounted for 91% of human-biting mosquitoes collected in the area. A total of 1126 mosquitoes were caught and dissected individually but none was infected with third-stage larvae (L3). Our findings support the phenomenon of facilitation, which predicts that Anopheles-transmitted lymphatic filariasis can be interrupted by mass chemotherapy alone in areas of low vector density and low transmission intensity as observed in the Hagahai.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Alpers, M P" sort="Alpers, M P" uniqKey="Alpers M" first="M P" last="Alpers">M P Alpers</name><name sortKey="Blakie, W M" sort="Blakie, W M" uniqKey="Blakie W" first="W M" last="Blakie">W M Blakie</name><name sortKey="Bockarie, M J" sort="Bockarie, M J" uniqKey="Bockarie M" first="M J" last="Bockarie">M J Bockarie</name><name sortKey="Jenkins, C" sort="Jenkins, C" uniqKey="Jenkins C" first="C" last="Jenkins">C. Jenkins</name><name sortKey="Lagog, M" sort="Lagog, M" uniqKey="Lagog M" first="M" last="Lagog">M. Lagog</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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